Tetrahedron Letters

A new method of forming resin bound thioesters and their use as 'traceless' linkers in solid phase synthesis

PJ May, M Bradley, DC Harrowven, D Pallin

文献索引：May, Peter J.; Bradley, Mark; Harrowven, David C.; Pallin, David Tetrahedron Letters, 2000 , vol. 41, # 10 p. 1627 - 1630

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被引用次数: 33

摘要

Thioesters are activated carboxylic acid derivatives which exhibit acylating properties similar to those of acid anhydrides. 1 Usually prepared by condensation of a thiol and an acid chloride, they have found widespread application in synthetic chemistry as precursors to aldehydes, ketones, acids, esters, lactones, amides, lactams and heterocycles. 2 Surprisingly, in view of the diverse chemistry this functional group offers, it has attracted ...