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Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl [1, 4] …

R Zanaletti, L Bettinetti, C Castaldo…

文献索引:Journal of Medicinal Chemistry, , vol. 55, # 10 p. 4806 - 4823

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被引用次数: 23

摘要

... Journal of Medicinal ... A medicinal chemistry effort, around our previously reported chemical series, permitted the discovery of a novel class of α7 nAChR ... are partially managed with current medications, cognitive deficits and negative symptoms still remain an unmet medical need. ...