Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists

N Kaila, K Janz, S DeBernardo…

文献索引：Journal of Medicinal Chemistry, , vol. 50, # 1 p. 21 - 39

全文：HTML全文

被引用次数: 86

摘要

... Journal of Medicinal ... High-throughput screening of the Wyeth chemical library identified the quinoline salicylic acid class of compounds (1) as antagonists of ... potency in in vitro and cell-based assays far superior to that of sLe x . Through iterative medicinal chemistry, we identified ...