Botulinum neurotoxin serotype A inhibitors: Small-molecule mercaptoacetamide analogs
…, AB Thompson, GM Smith, RA Fredenburg…
文献索引：Moe, Scott T.; Thompson, Andrew B.; Smith, Genessa M.; Fredenburg, Ross A.; Stein, Ross L.; Jacobson, Alan R. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 8 p. 3072 - 3079
Botulinum neurotoxin elicits its paralytic activity through a zinc-dependant metalloprotease that cleaves proteins involved in neurotransmitter release. Currently, no drugs are available to reverse the effects of botulinum intoxication. Herein we report the design of a novel series of mercaptoacetamide small-molecule inhibitors active against botulinum neurotoxin serotype A. These analogs show low micromolar inhibitory activity against the isolated ...
