N, N-Dimethyl-[9-(arylsulfonyl)-2, 3, 4, 9-tetrahydro-1H-carbazol-3-yl] amines as novel, potent and selective 5-HT 6 receptor antagonists

…, A Shinde, TR Bandyala, P Gudla, KK Kandukuri…

文献索引：Nirogi, Ramakrishna V. S.; Konda, Jagadishu Babu; Kambhampati, Ramasastry; Shinde, Anil; Bandyala, Thrinath Reddy; Gudla, Parandhama; Kandukuri, Kiran Kumar; Jayarajan, Pradeep; Kandikere, Vishwottam; Dubey, P. K. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6980 - 6985,6

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被引用次数: 7

摘要

The design, synthesis and SAR of novel tetrahydrocarbazole derivatives having 5-HT6 receptor antagonist activity is presented. The racemic compound 15e was found to possess desirable pharmacokinetic properties, adequate brain penetration and activity in animal models of cognition.