Journal of AOAC International 1995-01-01

Determination of hydramethylnon residues in grass by liquid chromatography with confirmation by liquid chromatography/mass spectrometry.

S J Stout, R P Peterson, A R daCuhna, G L Picard

文献索引：J. AOAC Int. 78(3) , 862-7, (1995)

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摘要

An improved method for determination of hydramethylnon residues in pasture grass is described. The method uses (1) the hydrochloride salt of hydramethylnon to improve its water solubility and (2) an acid-methanol precipitation to remove chlorophylls while leaving the analyte in solution. The liquid chromatographic method has a validated sensitivity of 0.05 ppm with controls showing < 0.004 ppm. The overall average recovery from 0.05 to 0.50 ppm was 98%, with a standard deviation of 11%. Samples showing a positive response (0.05 ppm or higher) and requiring mass spectrometric confirmation are directly amenable to liquid chromatography/mass spectrometry without additional sample preparation.