A new synthesis of 3H-pyrimidin-4-ones, characterized by four different sets of decorations, is presented. The strategy is based on the synthetic elaboration of readily available α- substituted β-ketoesters that, upon transformation into the corresponding acyl enamines, have been cyclized to give 6H-1, 3-oxazin-6-ones. These reactive intermediates have been in turn cleanly converted into highly functionalized pyirimidinones, by treatment with an ...
