Bioorganic & Medicinal Chemistry 2009-01-01

Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives

Lucie Szüčová, Lukáš Spíchal, Karel Doležal, Marek Zatloukal, Jarmila Greplová, Petr Galuszka, Vladimír Kryštof, Jiří Voller, Igor Popa, Frank J. Massino, Jan-Elo Jørgensen, Miroslav Strnad, Lucie Szüčová, Lukáš Spíchal, Karel Doležal, Marek Zatloukal, Jarmila Greplová, Petr Galuszka, Vladimír Kryštof, Jiří Voller, Igor Popa, Frank J. Massino, Jan-Elo Jørgensen, Miroslav Strnad

文献索引：Bioorg. Med. Chem. 17 , 1938-47, (2009)

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摘要

Synthesis of 9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-yl benzylaminopurines, their stability, cytokinin activity, perception by cytokinin receptors, degradation by cytokinin oxidase/dehydrogenase and cytotoxity against human diploid fibroblasts and selected human cancer cell lines in vitro are described.