Imidazo [1, 2-a] quinoxalines: synthesis and cyclic nucleotide phosphodiesterase inhibitory activity

…, G Subra, C Deleuze-Masquefa, V Benezech…

文献索引：Parra, Stephanie; Laurent, Florence; Subra, Guy; Deleuze-Masquefa, Carine; Benezech, Veronique; Fabreguettes, Jean-Roch; Vidal, Jean-Pierre; Pocock, Tristan; Elliott, Keith; Small, Roger; Escale, Roger; Michel, Alain; Chapat, Jean-Pierre; Bonnet, Pierre-Antoine European Journal of Medicinal Chemistry, 2001 , vol. 36, # 3 p. 255 - 264

全文：HTML全文

被引用次数: 22

摘要

A group of imidazo [1, 2-a] quinoxalines have been synthesised from quinoxaline by condensation of an appropriate haloester or intramolecular cyclisation of a keto moiety on an intracyclic nitrogen atom. The reactivity of the heterocycle was explored through diverse reactions such as electrophilic substitution, lithiation and halogen–metal exchange to give access to a new series of derivatives. Confirmation of their structure was mainly performed ...