The First Catalytic Method for Heck Alkynylation of Unactivated Aryl Bromides (Copper??Free Sonogashira) in an Ionic Liquid: 1 mol??% Palladium/Triphenylphosphane/ …

…, J Boudon, M Picquet, P Meunier

文献索引：Hierso, Jean-Cyrille; Boudon, Julien; Picquet, Michel; Meunier, Philippe European Journal of Organic Chemistry, 2007 , # 4 p. 583 - 587

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被引用次数: 25

摘要

Abstract Herein we report the studies of Heck alkynylation (copper-free Sonogashira) with aryl halides (I, Br, Cl) employing various metallic precursors, tertiary phosphanes and bases in [BMIM][BF 4] as the solvent. As a result, we provide the first method that allows the coupling of a large array of substrates, either activated or deactivated bromides in an ionic liquid. Furthermore, the system of highest efficiency is unexpectedly the simplest and ...