The use of Lewis acids in the synthesis of 5-arylhydantoins
…, G Lafuente, JA Mayoral, R Tahir, A Pallarés
文献索引：Cativiela, Carlos; Fraile, Jose M.; Garcia, Jose I.; Lafuente, Gustavo; Mayoral, Jose A.; Tahir, Rachid; Pallares, Antonio Journal of Catalysis, 2004 , vol. 226, # 1 p. 192 - 196
Different Lewis acids are able to promote the Friedel–Crafts reaction between 5- bromohydantoin and aromatic compounds. In the case of phenol, mixtures of ortho and para isomers are always obtained, with Mg (ClO4) 2 leading to the best selectivity. However, the best overall yield of 5-(hydroxyphenyl) hydantoin is obtained with YbCl3. This method can be extended to other aromatic systems such as anisole and thiophene. These reactions ...
