Bioorganic & medicinal chemistry letters

Discovery and structure–activity relationships of small molecules that block the human immunoglobulin G–human neonatal Fc receptor (hIgG–hFcRn) protein–protein …

Z Wang, C Fraley, AR Mezo

文献索引：Wang, Zhaolin; Fraley, Cara; Mezo, Adam R. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1253 - 1256

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被引用次数: 6

摘要

The neonatal Fc receptor, FcRn, prolongs the half-life of IgG in the serum and represents a potential therapeutic target for the treatment of autoimmune disease. Small molecules that block the protein–protein interactions of human IgG–human FcRn may lower pathogenic autoantibodies and provide effective treatment. A novel class of quinoxalines has been discovered as antagonists of the IgG: FcRn protein–protein interaction through ...