Metal-Based Drugs 1998-01-01

Synthesis, characterization and antitumour activity of metal complexes of 5-carboxy-2-thiouracil.

U P Singh, S Singh, S M Singh

文献索引：Met. Based Drugs 5 , 35-39, (1998)

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摘要

Metal complexes of 5-carboxy-2-thiouracil with Mn(ll), Co(ll), Ni(ll), Cu(ll), Zn(ll) and Cd(ll) ions were synthesized, characterized, and subjected to a screening system for evaluation of antitumour activity against Sarcoma-180 (S-180) tumour cells. The complexes were characterized by elemental analysis, infrared, electronic spectra, room temperature magnetic measurements and powder X-ray diffraction. The antitumour activity results indicate that some complexes have antitumour activity both in vivo and in vitro against S-180 tumour cells.