The synthesis of fexofenadine

W Ronggeng, Z Yougui, Z Guanchao

文献索引：Ronggeng, Wang; Yougui, Zhao; Guanchao, Zhang Research on Chemical Intermediates, 2013 , vol. 39, # 5 p. 2149 - 2155

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摘要

Abstract This work proposes a new simple route for fexofenadine synthesis with low cost and easily obtainable raw materials. We use benzene and methallyl as starting reactants, applying steps of Friedel–Crafts alkylation reaction, hydrolysis, oxidation, esterification reaction, and reduction reaction to obtain the intermediate product, followed by N-alkylation reaction to obtain 4-{1-hydroxy-4-[4-(hydroxydiphenyl)-piperidine] butyl}-α, α- ...