Facile synthesis of octahydrobenzo [h] isoquinolines: Novel and highly potent D 1 dopamine agonists

LA Bonner, BR Chemel, VJ Watts, DE Nichols

文献索引：Bonner, Lisa A.; Chemel, Benjamin R.; Watts, Val J.; Nichols, David E. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 18 p. 6763 - 6770

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被引用次数: 9

摘要

The octahydrobenzo [h] isoquinoline scaffold is of interest as a conformationally-restricted phenethylamine that may be useful for constructing biologically active products. Surprisingly, however, no tractable synthesis of this ring system has been reported. We now describe a facile method for obtaining this framework, and illustrate that our approach is easily amenable to substitutions at the 5-position. Importantly, we demonstrate that the 7, 8- ...