European journal of medicinal chemistry

Synthesis of 1-(4-acyloxybenzoyloxyacetyl)-4-alkylpiperazines and 1-(4-acyloxybenzoyl)-4-alkylpiperazines as inhibitors of chymotrypsin

P Zlatoidský, T Maliar

文献索引：Zlatoidsky; Maliar European Journal of Medicinal Chemistry, 1996 , vol. 31, # 9 p. 669 - 673

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被引用次数: 24

摘要

Sixteen new esters and amides of 4-acyloxybenzoic acids were prepared and screened as chymotrypsin inhibitors. Inhibiting activities on chymotrypsin differed markedly (> 100− 0.008 μM). Compounds which contained the 4-benzoyloxyacetyl moiety showed considerably higher activity then 4-acyloxybenzamides. Compounds 1c and 11f are also weak trypsin inhibitors.