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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

The Synthesis of Antineoplastic Agents. XXXII. N-Nitrosoureas. 1 I.

TP Johnston, GS McCaleb…

文献索引：Johnston,T.P. et al. J. Med. Chem., 1963 , vol. 6, p. 669 - 681

全文：HTML全文

被引用次数: 105

摘要

The reported ability of 1-methyl-3-nitro-1-nitrosoguanidine to increase the life span of mice implanted intraperitoneally with Leukemia L12102 prompted us to investigate the anticancer activity of the closely related compound, 1-methyl-1-nitro~ ourea.~ Although this compound showed only borderline activity against Adenocarcinoma 755 and Sarcoma 180, it proved even more effective, in our hands, against Leukemia L1210 than l-methyl-3-nitro-l- ...

异氰酸甲酯结构式

异氰酸甲酯

2-胺基乙酸乙酯结构式

2-胺基乙酸乙酯

~%

Glycine,N-[(methylamino)carbonyl]-, ethyl ester结构式

Glycine,N-[(met...

Urea,N-[(4-chlorophenyl)methyl]-N'-methyl-结构式

Urea,N-[(4-chlo...

~%

Urea,N,N'-bis[(4-chlorophenyl)methyl]-N'-nitroso-结构式

Urea,N,N'-bis[(...

3-[(4-chlorophenyl)methyl]-1-methyl-1-nitroso-urea结构式

3-[(4-chlorophe...

~%

Urea,N,N'-bis[(4-chlorophenyl)methyl]-N'-nitroso-结构式

Urea,N,N'-bis[(...

4-氯苄胺结构式

~%

Urea,N,N'-bis[(4-chlorophenyl)methyl]-N'-nitroso-结构式

Urea,N,N'-bis[(...

1,3-bis[(4-chlorophenyl)methyl]urea结构式

1,3-bis[(4-chlo...

~%

Urea,N,N'-bis[(4-chlorophenyl)methyl]-N'-nitroso-结构式

Urea,N,N'-bis[(...

3-methyl-1-(2,2,2-trifluoroethyl)urea结构式

3-methyl-1-(2,2...

~%

Urea,N-methyl-N-nitroso-N'-(2,2,2-trifluoroethyl)-结构式

Urea,N-methyl-N...

1,3-bis(2-cyanoethyl)urea结构式

1,3-bis(2-cyano...

~%

1,3-bis(2-cyanoethyl)-1-nitroso-urea结构式

1,3-bis(2-cyano...

异氰酸甲酯结构式

异氰酸甲酯

β-巯基乙胺结构式

β-巯基乙胺

~%

1-methyl-3-(2-sulfanylethyl)urea结构式

1-methyl-3-(2-s...

3,3'-亚胺二丙腈结构式

3,3'-亚胺二丙腈

异氰酸甲酯结构式

异氰酸甲酯

~%

1,1-bis(2-cyanoethyl)-3-methyl-urea结构式

1,1-bis(2-cyano...

对氨基苯甲酸结构式

对氨基苯甲酸

异氰酸甲酯结构式

异氰酸甲酯

~%

4-(methylcarbamoylamino)benzoic acid结构式

4-(methylcarbam...

氰酸钾结构式

3-aminopropanenitrile,hydrochloride结构式

3-aminopropanen...

~%

Urea, N-(2-cyanoethyl)-结构式

Urea, N-(2-cyan...

二乙醇胺结构式

异氰酸甲酯结构式

异氰酸甲酯

~%

1,1-bis(2-hydroxyethyl)-3-methyl-urea结构式

1,1-bis(2-hydro...

酪胺结构式

~%

[4-[2-[(methyl-nitroso-carbamoyl)amino]ethyl]phenyl] N-methyl-N-nitroso-carbamate结构式

[4-[2-[(methyl-...

[4-[2-(methylcarbamoylamino)ethyl]phenyl] N-methylcarbamate结构式

[4-[2-(methylca...

~%

[4-[2-[(methyl-nitroso-carbamoyl)amino]ethyl]phenyl] N-methyl-N-nitroso-carbamate结构式

[4-[2-[(methyl-...

异氰酸甲酯结构式

异氰酸甲酯

β-巯基乙胺结构式

β-巯基乙胺

~%

N-methyl-1-[2-(methylcarbamoylamino)ethylsulfanyl]formamide结构式

N-methyl-1-[2-(...

3-氨基丙腈结构式

异氰酸甲酯结构式

异氰酸甲酯

~%

Urea,N-(2-cyanoethyl)-N'-methyl-结构式

Urea,N-(2-cyano...

Glycine,N-[[(2-chloroethyl)amino]carbonyl]-, ethyl ester结构式

Glycine,N-[[(2-...

~%

Glycine,N-[[(2-chloroethyl)nitrosoamino]carbonyl]-, ethyl ester结构式

Glycine,N-[[(2-...

Urea,N-[(4-chlorophenyl)methyl]-N'-methyl-结构式

Urea,N-[(4-chlo...

~%

1,3-bis[(4-chlorophenyl)methyl]urea结构式

1,3-bis[(4-chlo...

4-氯苄胺结构式

~%

1,3-bis[(4-chlorophenyl)methyl]urea结构式

1,3-bis[(4-chlo...

3-[(4-chlorophenyl)methyl]-1-methyl-1-nitroso-urea结构式

3-[(4-chlorophe...

4-氯苄胺结构式

~%

1,3-bis[(4-chlorophenyl)methyl]urea结构式

1,3-bis[(4-chlo...

异氰酸甲酯结构式

异氰酸甲酯

对氨基乙酰苯胺结构式

对氨基乙酰苯胺

~%

Acetamide,N-[4-[[(methylamino)carbonyl]amino]phenyl]-结构式

Acetamide,N-[4-...

对氨基苯甲酸乙酯结构式

对氨基苯甲酸乙酯

~%

Benzoic acid,4-[[(methylnitrosoamino)carbonyl]amino]-, ethyl ester结构式

Benzoic acid,4-...

ethyl 4-(methylcarbamoylamino)benzoate结构式

ethyl 4-(methyl...

~%

Benzoic acid,4-[[(methylnitrosoamino)carbonyl]amino]-, ethyl ester结构式

Benzoic acid,4-...

3-methyl-1-[2-[2-(methylcarbamoylamino)ethyldisulfanyl]ethyl]urea结构式

3-methyl-1-[2-[...

~%

SRI 1630结构式

ethanimine结构式

异氰酸苯酯结构式

异氰酸苯酯

~%

1-(2-chloroethyl)-3-phenyl-urea结构式

1-(2-chloroethy...

4-氯苄胺结构式

异氰酸甲酯结构式

异氰酸甲酯

~%

Urea,N-[(4-chlorophenyl)methyl]-N'-methyl-结构式

Urea,N-[(4-chlo...

Urea,N-methyl-N-nitroso-N'-(2,2,2-trifluoroethyl)-结构式

Urea,N-methyl-N...

~%

1,3-bis(2,2,2-trifluoroethyl)urea结构式

1,3-bis(2,2,2-t...

Urea,N-(2-chloroethyl)-N'-(4-methoxyphenyl)-结构式

Urea,N-(2-chlor...

~%

Urea, 1-(2-chloroethyl)-3-(p-methoxyphenyl)-N-nitroso- (8CI)结构式

Urea, 1-(2-chlo...

4-甲氧基苯异氰酸酯结构式

4-甲氧基苯异氰酸酯

~%

Urea, 1-(2-chloroethyl)-3-(p-methoxyphenyl)-N-nitroso- (8CI)结构式

Urea, 1-(2-chlo...

1,2-Hydrazinedicarboxamide,N1,N2-dimethyl-结构式

1,2-Hydrazinedi...

~%

1,2-Hydrazinedicarboxamide,N1,N2-dimethyl-N1,N2-dinitroso-结构式

1,2-Hydrazinedi...

1,5-二氨基戊烷结构式

1,5-二氨基戊烷

甲基亚硝基脲结构式

甲基亚硝基脲

~%

5-(carbamoylamino)pentylurea结构式

5-(carbamoylami...

4-氯苄胺结构式

~%

3-[(4-chlorophenyl)methyl]-1-methyl-1-nitroso-urea结构式

3-[(4-chlorophe...

Urea,N-[(4-chlorophenyl)methyl]-N'-methyl-结构式

Urea,N-[(4-chlo...

~%

3-[(4-chlorophenyl)methyl]-1-methyl-1-nitroso-urea结构式

3-[(4-chlorophe...

3-methyl-1-[2-(methylcarbamoylamino)ethyl]urea结构式

3-methyl-1-[2-(...

~%

Urea,N,N''-1,2-ethanediylbis[N'-methyl-N'-nitroso- (9CI)结构式

Urea,N,N''-1,2-...

1-methyl-1-nitroso-3-phenethyl-urea结构式

1-methyl-1-nitr...

~%

1,3-bis(2-phenylethyl)urea结构式

1,3-bis(2-pheny...

3-methyl-1-phenethyl-urea结构式

3-methyl-1-phen...

~%

1,3-bis(2-phenylethyl)urea结构式

1,3-bis(2-pheny...

ethanimine结构式

4-氯苯基异氰酸酯结构式

4-氯苯基异氰酸酯

~%

1-(2-chloroethyl)-3-(4-chlorophenyl)urea结构式

1-(2-chloroethy...

对氨基苯甲酸结构式

对氨基苯甲酸

~%

SRI 1690结构式

4-(methylcarbamoylamino)benzoic acid结构式

4-(methylcarbam...

~%

SRI 1690结构式

β-苯乙胺结构式

~%

1-methyl-1-nitroso-3-phenethyl-urea结构式

1-methyl-1-nitr...

3-methyl-1-phenethyl-urea结构式

3-methyl-1-phen...

~%

1-methyl-1-nitroso-3-phenethyl-urea结构式

1-methyl-1-nitr...

对氨基-N,N-二甲基苯胺结构式

对氨基-N,N-二甲基苯胺

异氰酸甲酯结构式

异氰酸甲酯

~%

Urea,N-[4-(dimethylamino)phenyl]-N'-methyl-结构式

Urea,N-[4-(dime...

2,2,2-三氟乙胺盐酸盐结构式

2,2,2-三氟乙胺盐酸盐

异氰酸甲酯结构式

异氰酸甲酯

~%

3-methyl-1-(2,2,2-trifluoroethyl)urea结构式

3-methyl-1-(2,2...

酪胺结构式

异氰酸甲酯结构式

异氰酸甲酯

~%

[4-[2-(methylcarbamoylamino)ethyl]phenyl] N-methylcarbamate结构式

[4-[2-(methylca...

异氰酸甲酯结构式

异氰酸甲酯

对氨基苯甲酸乙酯结构式

对氨基苯甲酸乙酯

~%

ethyl 4-(methylcarbamoylamino)benzoate结构式

ethyl 4-(methyl...

异氰酸甲酯结构式

异氰酸甲酯

~%

1,2-Hydrazinedicarboxamide,N1,N2-dimethyl-结构式

1,2-Hydrazinedi...

2-氨基乙醇结构式

异氰酸甲酯结构式

异氰酸甲酯

~%

2-(methylcarbamoylamino)ethyl N-methylcarbamate结构式

2-(methylcarbam...

氮丙啶结构式

二甲氨基甲酰氯结构式

二甲氨基甲酰氯

~%

3-(2-chloroethyl)-1,1-dimethyl-urea结构式

3-(2-chloroethy...

对氨基苯酚结构式

对氨基苯酚

异氰酸甲酯结构式

异氰酸甲酯

~%

1-(4-羟基苯基l)-3-甲基脲结构式

1-(4-羟基苯基l)-3-甲基脲

1,5-二氨基戊烷结构式

1,5-二氨基戊烷

~%

1-methyl-3-[5-[(methyl-nitroso-carbamoyl)amino]pentyl]-1-nitroso-urea结构式

1-methyl-3-[5-[...

3-methyl-1-[5-(methylcarbamoylamino)pentyl]urea结构式

3-methyl-1-[5-(...

~%

1-methyl-3-[5-[(methyl-nitroso-carbamoyl)amino]pentyl]-1-nitroso-urea结构式

1-methyl-3-[5-[...

异氰酸甲酯结构式

异氰酸甲酯

对苯二胺结构式

~%

Urea,1,1'-p-phenylenebis[3-methyl- (7CI)结构式

Urea,1,1'-p-phe...

1,5-二氨基戊烷结构式

1,5-二氨基戊烷

Urea,N,N'-dimethyl-N'-nitroso-结构式

Urea,N,N'-dimet...

~%

3-methyl-1-[5-(methylcarbamoylamino)pentyl]urea结构式

3-methyl-1-[5-(...

乙二胺结构式

异氰酸甲酯结构式

异氰酸甲酯

~%

3-methyl-1-[2-(methylcarbamoylamino)ethyl]urea结构式

3-methyl-1-[2-(...

1-(2-chloroethyl)-3-(4-chlorophenyl)urea结构式

1-(2-chloroethy...

~%

1-(2-chloroethyl)-3-(4-chlorophenyl)-1-nitroso-urea结构式

1-(2-chloroethy...

4-氯苯基异氰酸酯结构式

4-氯苯基异氰酸酯

~%

1-(2-chloroethyl)-3-(4-chlorophenyl)-1-nitroso-urea结构式

1-(2-chloroethy...

异氰酸甲酯结构式

异氰酸甲酯

苄胺结构式

~%

1-benzyl-3-methyl-urea结构式

1-benzyl-3-meth...

β-苯乙胺结构式

异氰酸甲酯结构式

异氰酸甲酯

~%

3-methyl-1-phenethyl-urea结构式

3-methyl-1-phen...

对苯二胺结构式

~%

Urea, N,N-1,4-phenylenebis[N-methyl-N-nitroso-结构式

Urea, N,N-1,4-p...

Urea,1,1'-p-phenylenebis[3-methyl- (7CI)结构式

Urea,1,1'-p-phe...

~%

Urea, N,N-1,4-phenylenebis[N-methyl-N-nitroso-结构式

Urea, N,N-1,4-p...

氰酸钾结构式

2,2,2-三氟乙胺盐酸盐结构式

2,2,2-三氟乙胺盐酸盐

~%

N-(2,2,2-三氟乙基)脲结构式

N-(2,2,2-三氟乙基)脲

4-氟苯胺结构式

~%

3-(4-fluorophenyl)-1-methyl-1-nitroso-urea结构式

3-(4-fluorophen...

N-甲酰基甘氨酸乙酯结构式

N-甲酰基甘氨酸乙酯

~%

ethyl 2-(ethoxycarbonylmethylcarbamoylamino)acetate结构式

ethyl 2-(ethoxy...

磺胺结构式

异氰酸甲酯结构式

异氰酸甲酯

~%

3-methyl-1-[4-(methylcarbamoylamino)phenyl]sulfonyl-urea结构式

3-methyl-1-[4-(...

Urea,N-(2-cyanoethyl)-N'-methyl-结构式

Urea,N-(2-cyano...

~%

3-(2-cyanoethyl)-1-methyl-1-nitroso-urea结构式

3-(2-cyanoethyl...

胱胺结构式

Urea,N,N'-dimethyl-N'-nitroso-结构式

Urea,N,N'-dimet...

~%

3-methyl-1-[2-[2-(methylcarbamoylamino)ethyldisulfanyl]ethyl]urea结构式

3-methyl-1-[2-[...

Base catalyzed cyclization of substituted esters of hydantoi...

[Kavalek, Jaromir; Machacek, Vladimir; Svobodova, Gabriela; Sterba, Vojeslav Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 2 p. 375 - 390]