Asymmetric cyclopropanations by rhodium (II) N-(arylsulfonyl) prolinate catalyzed decomposition of vinyldiazomethanes in the presence of alkenes. Practical …

…, PR Bruzinski, DH Lake, N Kong, MJ Fall

文献索引：Davies, Huw M. L.; Bruzinski, Paul R.; Lake, Debra H.; Kong, Norman; Fall, Michael J. Journal of the American Chemical Society, 1996 , vol. 118, # 29 p. 6897 - 6907

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被引用次数: 391

摘要

The rhodium N-(arylsulfonyl) prolinate catalyzed decomposition of vinyldiazomethanes in the presence of alkenes leads to a very general method for the synthesis of functionalized cyclopropanes in a highly diastereoselective and enantioselective mode. A detailed study was undertaken to determine the key factors that control the enantioselectivity of this process. The highest levels of enantioselectivity were obtained using cyclic N-(arylsulfonyl ...