Carbohydrate Research 2009-07-27

Concise synthesis of two natural triterpenoid saponins, oleanolic acid derivatives isolated from the roots of Pulsatilla chinensis.

Qingchao Liu, Peng Wang, Lei Zhang, Tiantian Guo, Guokai Lv, Yingxia Li

文献索引：Carbohydr. Res. 344(11) , 1276-81, (2009)

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摘要

The first synthesis of two natural triterpenoid saponins, which were isolated from the roots of Pulsatilla chinensis and exhibited excellent in vitro cytotoxic activity against HL-60 cells, was concisely achieved in a convergent approach. We employed an odourless 2-methyl-5-tert-butylphenyl (Mbp) thioglycoside and trichloroacetimidate donors in one-pot reaction as a key step.