Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents

JF Cheng, Y Huang, R Penuliar…

文献索引：Journal of Medicinal Chemistry, , vol. 49, # 14 p. 4055 - 4058

全文：HTML全文

被引用次数: 27

摘要

... Journal of Medicinal Chemistry. ... 11,15 The IC 50 values of the synthesized compounds are tabulated in Tables 1 and 2. The most potent compounds were further profiled in terms of in vitro pharmaceutical properties (solubility, Caco-2 permeability, rat and human metabolic ...