Organic letters

Carbonylative Cross-Coupling of ortho-Disubstituted Aryl Iodides. Convenient Synthesis of Sterically Hindered Aryl Ketones

BM O'Keefe, N Simmons, SF Martin

文献索引：Michael O'Keefe; Simmons, Nicholas; Martin, Stephen F. Organic Letters, 2008 , vol. 10, # 22 p. 5301 - 5304

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被引用次数: 63

摘要

A mild and general protocol for the carbonylative cross-coupling of sterically hindered ortho- disubstituted aryl iodides is reported. Carbonylative Suzuki− Miyaura couplings of a variety of aryl boronic acids provide an array of substituted biaryl ketones in modest to excellent yield. A carbonylative Negishi coupling that utilizes alkynyl nucleophiles is also described.