Synthesis and structure–activity relationships of piperidinylpyrrolopyridine derivatives as potent and selective H 1 antagonists

…, D Vilella, M Aparici, J Prieto, G Warrellow…

文献索引：Fonquerna, Silvia; Miralpeix, Montse; Pages, Lluis; Puig, Carles; Cardus, Arantxa; Anton, Francisca; Vilella, Dolors; Aparici, Monica; Prieto, Jose; Warrellow, Graham; Beleta, Jorge; Ryder, Hamish Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1165 - 1167

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被引用次数: 16

摘要

The synthesis and structure–activity relationships of piperidinylpyrrolopyridines as potent and selective H1 antagonists are discussed. It was found that the nature of the acid chain bonded to piperidine was a key feature for maintaining both the duration of action in vivo and lack of sedative properties.