Bioorganic & Medicinal Chemistry Letters 1998-02-03

Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates.

H T Lee, W H Roark, J A Picard, D R Sliskovic, B D Roth, R L Stanfield, K L Hamelehle, R F Bousley, B R Krause

文献索引：Bioorg. Med. Chem. Lett. 8(3) , 289-94, (1998)

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摘要

Sulfoacetic acid, phosphoramidate, and phosphoramide analogs of the ACAT inhibitors, CI-999 and CI-1011 were synthesized. The structure-activity relationships of these compounds as ACAT inhibitors are described.