Synthesis, cytotoxic evaluation, and in silico studies of substituted N-alkylbromo-benzothiazoles

…, G Singh, A Sharma, PMS Bedi, AK Saxena

文献索引：Gill, Rupinder Kaur; Singh, Gagandeep; Sharma, Anuradha; Bedi; Saxena Medicinal Chemistry Research, 2013 , vol. 22, # 9 p. 4211 - 4222

全文：HTML全文

被引用次数: 6

摘要

Abstract In efforts to develop a new class of anticancer agents with improved efficacy and selective action, a series of N-alkylbromo-benzothiazoles were synthesized and evaluated for in vitro cytotoxic activity against various human cancer cell lines such as lung (A-549), prostate (PC-3), leukemia (THP-1), and colon (Caco-2). They were found to be highly active against prostate (PC-3) and leukemia (THP-1) cancer cells, moderately active against ...