Synthesis of 2-amino acids via selective mono-N-alkylation of trichloroacetamide by 2-bromo carboxylic esters under solid-liquid phase-transfer catalysis conditions

D Albanese, D Landini, M Penso

文献索引：Albanese, Domenico; Landini, Dario; Penso, Michele Journal of Organic Chemistry, 1992 , vol. 57, # 5 p. 1603 - 1605

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被引用次数: 21

摘要

In a previous paper'we described a new procedure for the synthesis of 2-amino acids 6 via N- alkylation of trifluoroacetamide (1) with 2-bromo carboxylic esters 3 under solid-liquid phase- transfer catalysis (SL-PTC) conditions, followed by hydrolysis of the intermediate N- (trifluoroacetyl)-2-amino esters 4 (Scheme I). The use of an excess of Wuoroacetamide (I), which cannot be recovered at the end of the reaction, and its relatively high cost are ...