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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

A New General Approach to Enantiomerically Pure Cyclic and Open??Chain (R)??and (S)?螃?, α??Disubstituted α??Amino Acids

…, P Schönholzer, K Müller, H Heimgartner…

文献索引：Obrecht; Spiegler; Schonholzer; Muller; Heimgartner; Stierli Helvetica Chimica Acta, 1992 , vol. 75, # 5 p. 1666 - 1696

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被引用次数: 89

摘要

Abstract A wide range of cyclic and open-chain α, α-disubstituted α-amino acids 1a-p were prepared. The racemic N-acylated α, α-disubstituted amino acids were resolved by coupling to chiral amines 15-18 derived from (S)-phenylalanine to form diastereoisomers 19/20 or 21/22 that could be separated by crystallization and/or flash chromatography on silica gel (Scheme 3). Selective cleavage via the 1, 3-oxazol-5 (4H)-ones 10a-p gave the ...

四氢吡咯结构式

BOC-L-苯丙氨酸结构式

BOC-L-苯丙氨酸

~%

(S)-2-氨基-3-苯基-1-(吡咯烷-1-基)丙-1-酮结构式

(S)-2-氨基-3-苯基-1...

5-(4'-METHOXYBENZYL)-5-METHYLHYDANTOIN结构式

5-(4'-METHOXYBE...

~93%

O-α-二甲基酪氨酸结构式

O-α-二甲基酪氨酸

对甲氧基苯基丙酮结构式

对甲氧基苯基丙酮

氰化钾结构式

~94%

5-(4'-METHOXYBENZYL)-5-METHYLHYDANTOIN结构式

5-(4'-METHOXYBE...

3',4'-dihydro-5'-methoxyspiro[imidazolidine-4,2'(1'H)-naphthalene]-2,5-dione结构式

3',4'-dihydro-5...

~87%

2-amino-5-methoxy-3,4-dihydro-1H-naphthalene-2-carboxylic acid结构式

2-amino-5-metho...

5-甲氧基-2-萘满酮结构式

5-甲氧基-2-萘满酮

~%

2-amino-5-methoxy-3,4-dihydro-1H-naphthalene-2-carboxylic acid结构式

2-amino-5-metho...

环丙甲基酮结构式

环丙甲基酮

氰化钾结构式

~79%

5-cyclopropyl-5-methyl-imidazolidine-2,4-dione结构式

5-cyclopropyl-5...

N2-((S)-N2-acetylvalyl)-L-phenylalanine dimethylamide结构式

N2-((S)-N2-acet...

~91%

N-乙酰-L-缬氨酸结构式

N-乙酰-L-缬氨酸

3',4'-dihydro-8'-methoxyspiro[imidazolidine-4,2'(1'H)-naphthalene]2,5-dione结构式

3',4'-dihydro-8...

~82%

2-氨基-8-甲氧基-1,2,3,4-四氢萘-2-羧酸结构式

2-氨基-8-甲氧基-1,2,...

8-甲氧基-β-四氢萘酮结构式

8-甲氧基-β-四氢萘酮

~%

2-氨基-8-甲氧基-1,2,3,4-四氢萘-2-羧酸结构式

2-氨基-8-甲氧基-1,2,...

3-phenyl-2-[(2-phenylacetyl)amino]propanoic acid结构式

3-phenyl-2-[(2-...

~%

N-(苯乙酰)-L-苯丙氨酸结构式

N-(苯乙酰)-L-苯丙氨酸

氰化钾结构式

β-四氢萘酮结构式

β-四氢萘酮

~90%

替群妥英结构式

N2-[(S)-N2-(phenylacetyl)phenylalanyl]-L-phenylalanine dimethylamide结构式

N2-[(S)-N2-(phe...

~76%

N-(苯乙酰)-L-苯丙氨酸结构式

N-(苯乙酰)-L-苯丙氨酸

2,4-dibenzyl-4H-oxazol-5-one结构式

2,4-dibenzyl-4H...

~%

N-(苯乙酰)-L-苯丙氨酸结构式

N-(苯乙酰)-L-苯丙氨酸

5-cyclopropyl-5-methyl-imidazolidine-2,4-dione结构式

5-cyclopropyl-5...

~97%

2-氨基-2-环丙基丙酸结构式

2-氨基-2-环丙基丙酸

环丙甲基酮结构式

环丙甲基酮

~%

2-氨基-2-环丙基丙酸结构式

2-氨基-2-环丙基丙酸

6-甲氧基-2-四氢萘酮结构式

6-甲氧基-2-四氢萘酮

~%

2-氨基-6-甲氧基-1,2,3,4-四氢萘-2-羧酸结构式

2-氨基-6-甲氧基-1,2,...

6,7-二甲氧基-3,4-二氢-1H-2-萘酮结构式

6,7-二甲氧基-3,4-二氢...

氰化钾结构式

~84%

2-spirohydantoin-6,7-dimethoxytetrahydronaphthalene结构式

2-spirohydantoi...

7-Methoxyspiro[tetralin-2,4'-imidazolidine]-2',5'-dione结构式

7-Methoxyspiro[...

~91%

2-amino-7-methoxy-3,4-dihydro-1H-naphthalene-2-carboxylic acid结构式

2-amino-7-metho...

7-甲氧基-2-萘满酮结构式

7-甲氧基-2-萘满酮

~%

2-amino-7-methoxy-3,4-dihydro-1H-naphthalene-2-carboxylic acid结构式

2-amino-7-metho...