A novel approach for the stereochemical assignment of carboxylic acid groups via the circular dichroism (CD) exciton chirality method using the 2-naphthyl chromophore is described. Direct esterification of carboxyl groups with 2-naphthol was effectively achieved with the employment of N, N-bis [2-oxo-3-oxazolidinyl] phosphorodiamidic chloride as the activating reagent. The method was tested with several model compounds, including both ...
