Tetrahedron Letters

8-Bromination of 2, 6, 9-trisubstituted purines with pyridinium tribromide

D Bliman, M Pettersson, M Bood, M Grøtli

文献索引：Bliman, David; Pettersson, Mariell; Bood, Mattias; Grotli, Morten Tetrahedron Letters, 2014 , vol. 55, # 18 p. 2929 - 2931

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被引用次数: 4

摘要

Abstract 2, 6, 9-Trisubstituted purines are brominated in high yields using pyridinium tribromide as the brominating reagent. This procedure works excellently for electron-rich purines having electron-donating substituents at the 2-and 6-positions. The use of pyridinium tribromide, a crystalline alternative to elemental bromine, improves the bromination procedure for this type of substrate as the reagent is easy to handle and the ...