Targeting ketone drugs towards transport by the intestinal peptide transporter, PepT1

D Foley, P Bailey, M Pieri, D Meredith

文献索引：Organic and Biomolecular Chemistry, , vol. 7, # 6 p. 1064 - 1067

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被引用次数: 19

摘要

... ethers are considerably more stable, there is sufficient precedent for their chemical and metabolic ... yields (56–85%) using either standard sodium hydride based desymmetrisation chemistry or the ... prodrugs will increase the number of tools available to medicinal chemists for drug ...