Pyrazolo [3, 4-b] quinoxalines. A new class of cyclin-dependent kinases inhibitors

…, B Zarranz, A Jaso, I Aldana, S Leclerc, L Meijer…

文献索引：Ortega, Miguel A.; Montoya, Maria E.; Zarranz, Belen; Jaso, Andres; Aldana, Ignacio; Leclerc, Sophie; Meijer, Laurent; Monge, Antonio Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 7 p. 2177 - 2184

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被引用次数: 38

摘要

Protein kinases are involved in most physiological processes and in numerous diseases. Therefore, inhibitors of protein kinases have therefore a wide therapeutic potential. While screening for inhibitors of cyclin-depent kinases (CDK's) and glycogen synthase kinase-3 (GSK-3), we identified pyrazolo [3, 4-b] quinoxalines as sub-micromolar inhibitors of CDK1/cyclin B. A preliminary structure–activity relationship study suggests that this family ...