Organic letters

Palladium-catalyzed cleavage of O/N-propargyl protecting groups in aqueous media under a copper-free condition1

M Pal, K Parasuraman, KR Yeleswarapu

文献索引：Pal, Manojit; Parasuraman, Karuppasamy; Yeleswarapu, Koteswar Rao Organic Letters, 2003 , vol. 5, # 3 p. 349 - 352

全文：HTML全文

被引用次数: 82

摘要

A copper-free palladium-mediated cleavage of O/N-propargyl bonds in aqueous media has been investigated, affording a mild and convenient method for the deprotection of phenols and anilines. The methodology could be utilized for the selective removal of propargyl groups from aryl ethers and amines without affecting a variety of unprotected functional groups present in the substrates. The mechanism and scope of the reaction is discussed.