The reaction between peptide aldehydes and acylhydrazones affords derivatives that represent potential prodrugs for selective inhibition of lysosomal enzymes. BzPheal= Ala, obtained from the reaction between N-benzoyl+ phenylalaninal and N-acetyl-calanine hydrazide, has been most carefully studied. When BzPheal= Ala is introduced into ongoing reactions catalyzed by a-chymotrypsin or papain, the rate of these reactions diminishes ...
