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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Quaternary Salts of Halogenated Pyridines and Quinolines1

CT Bahner, WK Easley, MD Pickens…

文献索引：Bahner et al. Journal of the American Chemical Society, 1951 , vol. 73, p. 3499

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被引用次数: 10

摘要

Since certain quaternary salts of pyridine and quinoline have been reported to damage sarcoma cells in vivo2 we have prepared similar salts of several halogenated pyridines and quinolines for screening against sarcoma in mice3 and for correlation of biological effects and other properties with structure. were prepared by reaction of a halogenated heterocyclic base with the appropriate organic halide at 30-40'. When the reactants alone did not form ...

2-氯吡啶结构式

对-α-二溴苯乙酮结构式

对-α-二溴苯乙酮

~%

1-(4-bromophenyl)-2-(2-chloro-2H-pyridin-1-yl)ethanone结构式

1-(4-bromopheny...

2-溴吡啶结构式

2-溴-4'-氟苯乙酮结构式

2-溴-4'-氟苯乙酮

~%

2-(2-bromo-2H-pyridin-1-yl)-1-(4-fluorophenyl)ethanone结构式

2-(2-bromo-2H-p...

3-碘吡啶结构式

2-溴-4'-氟苯乙酮结构式

2-溴-4'-氟苯乙酮

~%

1-(4-fluorophenyl)-2-(5-iodopyridin-1-yl)ethanone结构式

1-(4-fluorophen...

2-氯吡啶结构式

2-溴-4'-碘苯乙酮结构式

2-溴-4'-碘苯乙酮

~%

2-(2-chloro-2H-pyridin-1-yl)-1-(4-iodophenyl)ethanone结构式

2-(2-chloro-2H-...

3-溴吡啶结构式

1-苯基-2-溴乙醇结构式

1-苯基-2-溴乙醇

~%

2-(5-bromopyridin-1-yl)-1-phenyl-ethanol结构式

2-(5-bromopyrid...

6-氯喹啉结构式

1,3-二溴-2-丙醇结构式

1,3-二溴-2-丙醇

~%

1-bromo-3-(6-chloroquinolin-1-yl)propan-2-ol结构式

1-bromo-3-(6-ch...

3-溴吡啶结构式

2-环己基溴乙烷结构式

2-环己基溴乙烷

~%

5-bromo-1-(2-cyclohexylethyl)pyridine结构式

5-bromo-1-(2-cy...

3-溴吡啶结构式

2-iodo-1-naphthalen-2-ylethanone结构式

2-iodo-1-naphth...

~%

2-(5-bromopyridin-1-yl)-1-naphthalen-2-yl-ethanone结构式

2-(5-bromopyrid...

3,5-二溴吡啶结构式

3,5-二溴吡啶

2-溴-4'-氟苯乙酮结构式

2-溴-4'-氟苯乙酮

~%

2-(3,5-dibromopyridin-1-yl)-1-(4-fluorophenyl)ethanone结构式

2-(3,5-dibromop...

3,5-二溴吡啶结构式

3,5-二溴吡啶

对-α-二溴苯乙酮结构式

对-α-二溴苯乙酮

~%

1-(4-bromophenyl)-2-(3,5-dibromopyridin-1-yl)ethanone结构式

1-(4-bromopheny...

6-氯喹啉结构式

对-α-二溴苯乙酮结构式

对-α-二溴苯乙酮

~%

Quinolinium,1-[2-(4-bromophenyl)-2-oxoethyl]-6-chloro-, bromide (1:1)结构式

Quinolinium,1-[...

3,5-二溴吡啶结构式

3,5-二溴吡啶

2-溴-3'-硝基苯乙酮结构式

2-溴-3'-硝基苯乙酮

~%

2-(3,5-dibromopyridin-1-yl)-1-(3-nitrophenyl)ethanone结构式

2-(3,5-dibromop...

3-溴吡啶结构式

~%

Pyridinium,3-bromo-1-[2-(4-chlorophenyl)-1-methyl-2-oxoethyl]-, bromide (1:1)结构式

Pyridinium,3-br...

6-氯喹啉结构式

2-溴-1-(4-(叔丁基)苯基)乙酮结构式

2-溴-1-(4-(叔丁基)苯基)乙酮

~%

Quinolinium,6-chloro-1-[2-[4-(1,1-dimethylethyl)phenyl]-2-oxoethyl]-, bromide (1:1)结构式

Quinolinium,6-c...

2-氯吡啶结构式

α-溴代-4-氯苯乙酮结构式

α-溴代-4-氯苯乙酮

~%

Pyridinium,2-chloro-1-[2-(4-chlorophenyl)-2-oxoethyl]-, bromide (1:1)结构式

Pyridinium,2-ch...

3-溴吡啶结构式

1-碘癸烷结构式

~%

5-bromo-1-decyl-pyridine结构式

5-bromo-1-decyl...

3-溴吡啶结构式

2-溴-1-(2,5-二氯苯基)乙酮结构式

2-溴-1-(2,5-二氯苯基)乙酮

~%

2-(5-bromopyridin-1-yl)-1-(2,5-dichlorophenyl)ethanone结构式

2-(5-bromopyrid...

2-溴吡啶结构式

2-溴-4'-碘苯乙酮结构式

2-溴-4'-碘苯乙酮

~%

2-(2-bromo-2H-pyridin-1-yl)-1-(4-iodophenyl)ethanone结构式

2-(2-bromo-2H-p...

3-溴吡啶结构式

2-溴-4'-氟苯乙酮结构式

2-溴-4'-氟苯乙酮

~%

Pyridinium,3-bromo-1-[2-(4-fluorophenyl)-2-oxoethyl]-, bromide (1:1)结构式

Pyridinium,3-br...

3,5-二溴吡啶结构式

3,5-二溴吡啶

α-溴代-4-氯苯乙酮结构式

α-溴代-4-氯苯乙酮

~%

Pyridinium,3,5-dibromo-1-[2-(4-chlorophenyl)-2-oxoethyl]-, bromide (1:1)结构式

Pyridinium,3,5-...

6-氯喹啉结构式

1-碘癸烷结构式

~%

6-chloro-1-decyl-quinoline结构式

6-chloro-1-decy...

3,5-二溴吡啶结构式

3,5-二溴吡啶

2-iodo-1-(5,6,7,8-tetrahydro-[2]naphthyl)-ethanone结构式

2-iodo-1-(5,6,7...

~%

2-(3,5-dibromopyridin-1-yl)-1-tetralin-2-yl-ethanone结构式

2-(3,5-dibromop...

3-溴吡啶结构式

碘代醋酸乙酯结构式

碘代醋酸乙酯

~%

ethyl 2-(5-bromopyridin-1-yl)acetate iodide结构式

ethyl 2-(5-brom...

3,5-二溴吡啶结构式

3,5-二溴吡啶

~%

5-(3-chloro-2-methyl-phenyl)-N-(9,10-dioxoanthracen-2-yl)furan-2-carboxamide结构式

5-(3-chloro-2-m...

3,5-二溴吡啶结构式

3,5-二溴吡啶

4-甲氧基-α－溴代苯乙酮结构式

4-甲氧基-α－溴代苯乙酮

~%

2-(3,5-dibromopyridin-1-yl)-1-(4-methoxyphenyl)ethanone结构式

2-(3,5-dibromop...

3,5-二溴吡啶结构式

3,5-二溴吡啶

2-溴-4-苯基乙酰苯结构式

2-溴-4-苯基乙酰苯

~%

2-(3,5-dibromopyridin-1-yl)-1-(4-phenylphenyl)ethanone结构式

2-(3,5-dibromop...

3-溴吡啶结构式

1,3-二溴-2-丙醇结构式

1,3-二溴-2-丙醇

~%

1-(3-bromo-1-piperidyl)-3-(3-bromo-6H-pyridin-1-yl)propan-2-ol结构式

1-(3-bromo-1-pi...

3-溴喹啉结构式

2-溴-4'-氟苯乙酮结构式

2-溴-4'-氟苯乙酮

~%

2-(3-bromoquinolin-1-yl)-1-(4-fluorophenyl)ethanone结构式

2-(3-bromoquino...

6-氯喹啉结构式

2-溴-3'-硝基苯乙酮结构式

2-溴-3'-硝基苯乙酮

~%

2-(6-chloroquinolin-1-yl)-1-(3-nitrophenyl)ethanone结构式

2-(6-chloroquin...

6-氯喹啉结构式

β-溴苯乙烷结构式

β-溴苯乙烷

~%

2-(1,3-dioxoisoindol-2-yl)-N-(6-methyl-3-prop-2-enyl-benzothiazol-2-ylidene)acetamide结构式

2-(1,3-dioxoiso...

3,5-二溴吡啶结构式

3,5-二溴吡啶

~%

1-(4-chlorophenyl)-2-(3,5-dibromopyridin-1-yl)propan-1-one结构式

1-(4-chlorophen...

3-溴吡啶结构式

4-甲氧基-α－溴代苯乙酮结构式

4-甲氧基-α－溴代苯乙酮

~%

2-(5-bromopyridin-1-yl)-1-(4-methoxyphenyl)ethanone结构式

2-(5-bromopyrid...

3-溴吡啶结构式

Ethanone,2-bromo-1-(4-fluoro-1-naphthalenyl)-结构式

Ethanone,2-brom...

~%

2-(5-bromopyridin-1-yl)-1-(4-fluoronaphthalen-1-yl)ethanone结构式

2-(5-bromopyrid...

6-氯喹啉结构式

2-萘基溴甲基酮结构式

2-萘基溴甲基酮

~%

2-(6-chloroquinolin-1-yl)-1-naphthalen-2-yl-ethanone结构式

2-(6-chloroquin...

2-溴吡啶结构式

α-溴代-4-氯苯乙酮结构式

α-溴代-4-氯苯乙酮

~%

Pyridinium, 2-bromo-1-[2-(4-chlorophenyl)-2-oxoethyl]-,bromide (1:1)结构式

Pyridinium, 2-b...

6-氯喹啉结构式

2-溴-1-(5,6,7,8-四氢萘-2-基)乙酮结构式

2-溴-1-(5,6,7,8-...

~%

2-(6-chloroquinolin-1-yl)-1-tetralin-2-yl-ethanone结构式

2-(6-chloroquin...

3-溴吡啶结构式

2-溴-3'-硝基苯乙酮结构式

2-溴-3'-硝基苯乙酮

~%

2-(5-bromopyridin-1-yl)-1-(3-nitrophenyl)ethanone结构式

2-(5-bromopyrid...

6-氯喹啉结构式

α-溴代-4-氯苯乙酮结构式

α-溴代-4-氯苯乙酮

~%

1-(4-chlorophenyl)-2-(6-chloroquinolin-1-yl)ethanone结构式

1-(4-chlorophen...

3,5-二溴吡啶结构式

3,5-二溴吡啶

2-iodo-1-naphthalen-2-ylethanone结构式

2-iodo-1-naphth...

~%

2-(3,5-dibromopyridin-1-yl)-1-naphthalen-2-yl-ethanone结构式

2-(3,5-dibromop...

2-溴吡啶结构式

2-溴-1-(5,6,7,8-四氢萘-2-基)乙酮结构式

2-溴-1-(5,6,7,8-...

~%

2-(2-bromo-2H-pyridin-1-yl)-1-tetralin-2-yl-ethanone结构式

2-(2-bromo-2H-p...

3-氯吡啶结构式

2-溴-4'-氟苯乙酮结构式

2-溴-4'-氟苯乙酮

~%

2-(5-chloropyridin-1-yl)-1-(4-fluorophenyl)ethanone结构式

2-(5-chloropyri...

3-溴吡啶结构式

α-溴代-4-氯苯乙酮结构式

α-溴代-4-氯苯乙酮

~%

2-(5-bromopyridin-1-yl)-1-(4-chlorophenyl)ethanone结构式

2-(5-bromopyrid...

3-氟吡啶结构式

2-溴-4'-氟苯乙酮结构式

2-溴-4'-氟苯乙酮

~%

1-(4-fluorophenyl)-2-(5-fluoropyridin-1-yl)ethanone结构式

1-(4-fluorophen...

6-氯喹啉结构式

4-甲氧基-α－溴代苯乙酮结构式

4-甲氧基-α－溴代苯乙酮

~%

2-(6-chloroquinolin-1-yl)-1-(4-methoxyphenyl)ethanone结构式

2-(6-chloroquin...

2-氯吡啶结构式

2-溴-4'-氟苯乙酮结构式

2-溴-4'-氟苯乙酮

~%

2-(2-chloro-2H-pyridin-1-yl)-1-(4-fluorophenyl)ethanone结构式

2-(2-chloro-2H-...