Synthesis and biological characterization of 1, 4, 5, 6-tetrahydropyrimidine and 2-amino-3, 4, 5, 6-tetrahydropyridine derivatives as selective m1 agonists

…, AA El-Assadi, S Sbeih, PG Dunbar…

文献索引：Messer Jr., William S.; Abuh, Yahaya F.; Liu, Yang; Periyasamy, Sumudra; Ngur, Dan O.; Edgar, Michael A. N.; El-Assadi, Afif A.; Sbeih, Sbeih; Dunbar, Philip G.; Roknich, Scott; Rho, Taikyun; Fang, Zheng; Ojo, Babatunde; Zhang, Hao; Huzl III, James J.; Nagy, Peter I. Journal of Medicinal Chemistry, 1997 , vol. 40, # 8 p. 1230 - 1246

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被引用次数: 74

摘要

Previous studies identified several novel tetrahydropyrimidine derivatives exhibiting muscarinic agonist activity in rat brain. Such compounds might be useful in treating cognitive and memory deficits associated with low acetylcholine levels, as found in Alzheimer's disease. To determine the molecular features of ligands important for binding and activity at muscarinic receptor subtypes, the series of tetrahydropyrimidines was extended. Several ...