Life Sciences 2009-01-01

Osthole activates glucose uptake but blocks full activation in L929 fibroblast cells, and inhibits uptake in HCLE cells

Ola D. Alabi, Stephen M. Gunnink, Benjamin D. Kuiper, Samuel A. Kerk, Emily Braun, Larry L. Louters

文献索引：Life Sci. 102(2) , 105-10, (2014)

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摘要

Aims Osthole, a coumarin derivative, has been used in Chinese medicine and studies have suggested a potential use in treatment of diabetes and cancers. Therefore, we investigated the effects of osthole and other coumarins on GLUT1 activity in two cell lines that exclusively express GLUT1.