Fully enzymatic peptide synthesis using C??terminal tert??butyl ester interconversion

T Nuijens, C Cusan, TJGM van Dooren…

文献索引：Nuijens, Timo; Cusan, Claudia; Van Dooren, Theodorus J. G. M.; Moody, Harold M.; Merkx, Remco; Kruijtzer, John A. W.; Rijkers, Dirk T. S.; Liskamp, Rob M. J.; Quaedflieg, Peter J. L. M. Advanced Synthesis and Catalysis, 2010 , vol. 352, # 14-15 p. 2399 - 2404

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被引用次数: 19

摘要

Abstract Chemoenzymatic peptide synthesis is potentially the most cost-efficient technology for the synthesis of short and medium-sized peptides with some important advantages. For instance, stoichiometric amounts of expensive coupling reagents are not required and racemisation does not occur, thus rendering purification easier compared to chemical peptide synthesis. The economically most attractive synthesis runs in the N [ ...