A facile synthesis of 9-deaza analogue of olomoucine

P Čapek, M Otmar, M Masojídková…

文献索引：Capek, Petr; Otmar, Miroslav; Masojidkova, Milena; Votruba, Ivan; Holy, Antonin Collection of Czechoslovak Chemical Communications, 2003 , vol. 68, # 4 p. 779 - 791

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被引用次数: 6

摘要

Abstract Heating of 6-(benzylamino)-2-chloro-9-deazapurine (3) with ethanolamine afforded 6-(benzylamino)-2-[(2-hydroxyethyl) amino]-9-deazapurine (8). Its treatment with formaldehyde in alkaline solution, after protection of the OH group with DMTr, led to hydroxymethylation at position 9. Conversion of the hydroxymethyl group to methyl was performed by catalytic hydrogenation under simultaneous deprotection, which resulted in ...