Green chemistry approach to the synthesis of N-substituted piperidones

MM Faul, ME Kobierski, ME Kopach

文献索引：Faul, Margaret M.; Kobierski, Michael E.; Kopach, Michael E. Journal of Organic Chemistry, 2003 , vol. 68, # 14 p. 5739 - 5741

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被引用次数: 15

摘要

An efficient green chemistry approach to the synthesis of N-substituted piperidones and piperidines was developed and applied to the synthesis of 1-(2-pyridinylmethyl)-piperidin-4- one, 1, a key starting material for the synthesis of LY317615, an antiangiogenic agent currently under development at Eli Lilly and Company (Chart 1). 1 The general utility of this methodology, which presents significant advantages over the classical Dieckman ...