Tetrahedron Letters

Platinum catalysed hydrolytic amidation of unactivated nitriles

CJ Cobley, M van den Heuvel, A Abbadi, JG de Vries

文献索引：Cobley, Christopher J.; Van Den Heuvel, Marco; Abbadi, Abdelilah; De Vries, Johannes G. Tetrahedron Letters, 2000 , vol. 41, # 14 p. 2467 - 2470

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被引用次数: 86

摘要

The platinum (II) complex,[(Me2PO·· H·· OPMe2) PtH (PMe2OH)], efficiently catalyses the direct conversion of unactivated nitriles to N-substituted amides with both primary and secondary amines. Possible mechanisms for this reaction are discussed and evidence for initial amidine formation is reported. Isolated yields vary from 51–89%.