Tetrahedron

A simple method for synthesis of amides and peptides through acyl chlorides: A rapid synthesis of thyrotropin releasing hormone

F Matsuda, S Itoh, N Hattori, M Yanagiya, T Matsumoto

文献索引：Matsuda, Fuyuhiko; Itoh, Shin; Hattori, Noritaka; Yanagiya, Mitsutoshi; Matsumoto, Takeshi Tetrahedron, 1985 , vol. 41, # 18 p. 3625 - 3631

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被引用次数: 33

摘要

By improvement of the classical SOCl2-pyridine method for the preparation of acid chlorides, amides and optically pure peptides were synthesized rapidly in a simple manner from DCHA dicyclohexylammonium) salts of carboxylic acids. This modified SOCl2-pyridine method was applied to a rapid synthesis of TRH.