Physical Review Letters 2014-01-17

Reentrant liquid-liquid phase separation in protein solutions at elevated hydrostatic pressures.

Johannes Möller, Sebastian Grobelny, Julian Schulze, Steffen Bieder, Andre Steffen, Mirko Erlkamp, Michael Paulus, Metin Tolan, Roland Winter

文献索引：Phys. Rev. Lett. 112(2) , 028101, (2014)

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摘要

We present results from small-angle x-ray scattering data on the effect of high pressure on the phase behavior of dense lysozyme solutions in the liquid-liquid phase separation region, and characterize the underlying intermolecular protein-protein interactions as a function of temperature and pressure in this region of phase space. A reentrant liquid-liquid phase separation region has been discovered at elevated pressures, which originates in the pressure dependence of the solvent-mediated protein-protein interactions.