Studies on antihypertensive agents with antithrombotic activity. 2. Syntheses and pharmacological evaluation of pyrrolo [2, 3-c] azepine derivatives.

…, T TATSUOKA, K NAKANISHI, C TAKIGUCHI…

文献索引：Mizuno; Miya; Kamei; Shibata; Tatsuoka; Nakanishi; Takiguchi; Hidaka; Yamaki; Inomata Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 8 p. 1129 - 1137

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被引用次数: 12

摘要

As an extension of our previous investigation, a series of 7-aminoalkylpyrrolo [2, 3-c] azepine derivatives was synthesized and evaluated as α 1-adrenergic-and serotonin 2 (5- HT 2)-receptor antagonists, with the aim of finding a novel potent antihypertensive agent with both activities. Among the compounds obtained in this study,(E)-1-ethyl-7-[3-[4-(4- fluorophenyl) piperazin-1-yl] propyl]-4-hydroxyimino-1, 4, 5, 6, 7, 8-hexahydropyrrolo [2, 3- ...