Tetrahedron letters

A one-step synthesis of pseudoephedrine glycinamide, a versatile precursor for the synthesis of α-amino acids

AG Myers, T Yoon, JL Gleason

文献索引：Myers, Andrew G.; Yoon, Taeyoung; Gleason, James L. Tetrahedron Letters, 1995 , vol. 36, # 26 p. 4555 - 4558

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被引用次数: 39

摘要

Both enantiomers of pseudoephedrine glycinamide [(+)-or (−)-1] were synthesized by either of two procedures:(1) a standard two-step coupling of N-Boc-Gly with pseudoephedrine followed by deprotection, or (2) a more economical one-step coupling reaction of Gly-OMe with pseudoephedrine mediated by LiCl and base.