Bioorganic & Medicinal Chemistry Letters 2005-12-15

Anti-malarial activity of Baylis-Hillman adducts from substituted 2-chloronicotinaldehydes.

P Narender, U Srinivas, B Gangadasu, Sukla Biswas, V Jayathirtha Rao

文献索引：Bioorg. Med. Chem. Lett. 15(24) , 5378-81, (2005)

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摘要

New Baylis-Hillman adducts are synthesized based on substituted 2-chloronicotinaldehydes and screened for their in vitro anti-malarial activity against chloroquine sensitive and chloroquine resistant Plasmodium falciparum. Out of the six new compounds synthesized and screened, 2b, 2c and 2d compounds showed substantial anti-malarial activity.