Journal of Peptide Science 2000-10-01

Improving the performance of an acid-labile 4-hydroxymethyl phenoxyacetic acid (HMP) linker on resin and SynPhase grafted solid-supports.

C T Bui, F Ercole, Y Pham, R Campbell, F A Rasoul, N J Maeji, N J Ede

文献索引：J. Pept. Sci. 6(10) , 534-8, (2000)

摘要

A replacement of the acetic acid moiety by valeric acid within the 4-hydroxymethylphenoxyacetic acid (HMP) linker (Sheppard RC, Williams BJ. Acid-labile resin linkage agents for use in solid phase peptide synthesis. Int. J. Peptide Protein Res. 1982; 20: 451-454) significantly improved its performance in terms of loading capacity, yield and purity of the final products. The results indicated the spacer-linker combination and type of solid supports are important factors for solid-phase synthesis.

结构式	名称/CAS号	分子式	全部文献
	4-(羟基甲基)苯氧基乙酸 CAS:68858-21-9	C₉H₁₀O₄

Acid-labile resin linkage agents for use in solid phase pept...
1982-11-01
[Int. J. Pept. Protein Res. 20(5) , 451-4, (1982)]

E. Atherton et al.
[J. Chem. Soc. Chem. Commun. , 537, (1978)]

[J. Chem. Soc. Chem. Commun. , 539, (1978)]

A. Dryland, R.C. Sheppard
[J. Chem. Soc. Perkin Trans. I , 125, (1986)]

Improving the performance of an acid-labile 4-hydroxymethyl phenoxyacetic acid (HMP) linker on resin and SynPhase grafted solid-supports.

摘要

相关化合物