Evidence for Existence of Intermediate in Acid Hydrolyses of Sulfinamide and Carboxamide

JP Lee, HE Yu, DI Jung, IS Koo

文献索引：Lee, Jong Pal; Yu, Hye Eun; Il Jung, Dai; Koo, In Sun Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 6 p. 1773 - 1775

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被引用次数: 1

摘要

(i) Acid hydrolysis reaction of sulfinamide and carboxamide takes place similarly and through an intermediate.(ii) A break of pH rate profile and the downward concave curve in buffer effect can be taken as definitive evidence for the existence of an intermediate. Hydrolyses of carboxamides, such as N-acylimidazoles, have been extensively studied in the aspect of similar role of histidine in enzyme reaction. 1 Most of them mainly ...