A simple method for the reduction of carboxylic acids to aldehydes or alcohols using H2 and Pd/C

M Falorni, G Giacomelli, A Porcheddu…

文献索引：Falorni, Massimo; Giacomelli, Giampaolo; Porcheddu, Andrea; Taddei, Maurizio Journal of Organic Chemistry, 1999 , vol. 64, # 24 p. 8962 - 8964

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被引用次数: 60

摘要

Aldehydes are versatile compounds in organic synthesis. Despite their intrinsic benefits, there are relatively few methods for their preparation. 1 A common approach to obtain aldehydes is in fact the oxidation of primary alcohols2 or the reduction of carboxylic acids and their derivatives. 3 This last transformation is particularly useful for the preparation of N- protected R-amino aldehydes4 that are valuable intermediates for the synthesis of ...