Biotransformation of halogenated 2′-deoxyribosides by immobilized lactic acid bacteria

CN Britos, VA Cappa, CW Rivero, JE Sambeth…

文献索引：Britos, Claudia N.; Cappa, Valeria A.; Rivero, Cintia W.; Sambeth, Jorge E.; Lozano, Mario E.; Trelles, Jorge A. Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 79, p. 49 - 53

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被引用次数: 10

摘要

An efficient and green bioprocess is herein reported to obtain halogenated nucleosides by transglycosylation using immobilized lactic acid bacteria (LAB). Lactobacillus animalis ATCC 35046 showed a yield of 95% at 0.5 h to synthesize 5-fluorouracil-2′-deoxyriboside (floxuridine). Calcium alginate was the best matrix for whole-cell immobilization by entrapment. Its productivity was 87mg/Lh in a continuous bioprocess. When adsorption ...