Abstract In a continuation of our studies involving the nucleophilic displacement of one of the chlorines from 2, 4, 6-trichloropyrimidine, we now report the initial displacement of one of the fluorine atoms from 2, 4, 6-trifluoropyrimidine using both aliphatic and aromatic amines. The monosubstitution products favor 2-substitution with ammonia and ethanolamine while aniline gave the 4-substituted derivative as the preferred product.
