Synthesis and biological evaluation of novel 2, 4, 5-substituted pyrimidine derivatives for anticancer activity

F Xie, H Zhao, L Zhao, L Lou, Y Hu

文献索引：Xie, Fuchun; Zhao, Hongbing; Zhao, Lizhi; Lou, Liguang; Hu, Youhong Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 1 p. 275 - 278

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被引用次数: 87

摘要

A series of novel 2, 4, 5-substituted pyrimidine derivatives were synthesized and evaluated for inhibition against the human hepatocellular carcinoma BEL-7402 cancer cell line. Several compounds showed potent inhibition with an IC50 value less than 0.10 μM. Structure–activity relationships for this class of compounds at the 2-and 5-position of the pyrimidine scaffold have been elucidated. The most active compound 7gc showed good ...